IBA ibalizumab-uiyk

For heavily treatment-experienced people
Entry Inhibitor

Standard Dose

Long-acting antiretroviral administered once every two weeks via intravenous infusion. Treatment begins with an IV loading (starting) dose of 2,000 mg, followed by an 800 mg IV infusion maintenance dose given every two weeks thereafter. Must be taken in combination with another antiretroviral(s).

The first infusion takes at least 30 minutes. If no infusion-related adverse events occur, subsequent infusions take 15 minutes. Doses may be administered every two weeks at an inpatient and/or outpatient setting, including at-home infusion, if desired. All patients should be observed for 1 hour after completing first infusion. If no infusion-associated adverse reaction is noted, the post-infusion observation time can be reduced to 15 minutes for subsequent doses. A Biologics License Application (sBLA) was submitted to the FDA in December 2021 for approval of an IV push formulation that administers undiluted Trogarzo over 30 seconds. Intramuscular administration is also being studied. Trogarzo must be given with an optimized background regimen (OBR). An OBR consists of the best antiretroviral therapy that can be selected for a patient based on the patterns of HIV drug resistance of their virus. Other considerations can include safety profile, tolerability, and lack of adverse drug-drug interactions or cross-resistance. Dose modifications of Trogarzo are not required when administered with any other antiretroviral or any other treatments.

If a maintenance dose of Trogarzo is missed by 3 days or longer beyond the scheduled dosing day, a loading dose (2,000 mg) should be administered as soon as possible. Then resume maintenance dosing (800 mg) every 14 days thereafter.
  • See package insert for more complete information on potential side effects and interactions.


TaiMed USA

Distributed by
Theratechnologies Inc.;


$3,211.20 per box (2 vials); 10 vials for loading dose and four vials for continuing dose (every two weeks)

Potential Side Effects and Toxicity

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