ibalizumab-uiyk IBA (long-acting EI)

Medication with unique mechanism of action, DHHS recommended for heavily treatment-experienced people
Entry Inhibitor

Standard Dose

Long-acting antiretroviral administered once every two weeks via intravenous infusion. Treatment begins with a single loading (starting) dose of 2,000 mg, followed by an 800 mg maintenance dose given every two weeks thereafter. The maintenance dose can be administered as a diluted IV infusion or undiluted IV push. Must be taken in combination with another antiretroviral(s).

The first infusion takes at least 30 minutes. If no infusion-related adverse events occur, subsequent infusions can be given as an IV infusion over 15 minutes or as an IV push over 30 seconds. Doses may be administered every two weeks at an inpatient and/or outpatient setting, including at-home infusion, if desired. All patients should be observed for 1 hour after completing first infusion. If no infusion-associated adverse reaction is noted, the post-infusion observation time can be reduced to 15 minutes for subsequent doses.

Trogarzo must be given with an optimized background regimen (OBR). An OBR consists of the best antiretroviral therapy that can be selected for a person based on the patterns of HIV drug resistance of their virus. Other considerations can include safety profile, tolerability, and lack of adverse drug-drug interactions or cross-resistance. Dose modifications of Trogarzo are not required when administered with any other antiretroviral or any other treatments.

If a maintenance dose of Trogarzo is missed by 3 days or longer beyond the scheduled dosing day, a loading dose (2,000 mg) should be administered as soon as possible. Then maintenance dosing (800 mg) can be resumed every 14 days thereafter.
  • See package insert for more complete information on potential side effects and interactions.


TaiMed USA

Distributed by Theratechnologies Inc.;


$3,435.60 per box (2 vials); 10 vials for loading dose and four vials for continuing dose (every two weeks)

Potential Side Effects and Toxicity

Potential Drug Interactions

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