Positively Aware Sustiva


600 mg efavirenz EFV (NNRTI)

Recommended as a component of initial regimen in certain clinical situations (as a component of Atripla, or in combination with Descovy, Truvada, Cimduo, or Temixys)
Non-Nucleoside "Non-Nuke"

Standard Dose

One tablet once daily on an empty stomach, preferably at bedtime (food can increase the risk of central nervous system, or CNS, side effects). Must be taken in combination with another antiretroviral(s) from a different drug class. Lower 400 mg dose available in the single-tablet regimen Symfi Lo (where it is combined with tenofovir DF and lamivudine; see Symfi Lo page).

Approved for adults and children 3 months and older weighing at least 7.7 pounds (3.5 kg). DHHS guidelines, however, do not recommend use for children aged 3 months up to three years or weighing less than 28.5 pounds (13 kg), due to issues with drug levels; see pediatric guidelines. For children weighing less than 88 pounds (40 kg), the dose is based on weight. See package insert for specific weight-based dosing. For children weighing at least 88 pounds, use the standard adult dose. For those who can’t swallow capsules, administer by capsule sprinkle method. See drug label for instructions or watch the video at sustiva.com.

Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose. Also available in 50 mg and 200 mg capsules.

Use with caution in mild liver impairment; not recommended with moderate or severe liver impairment.
  • See package insert for more complete information on potential side effects and interactions.
  • Generic Sustiva is available


Bristol-Myers Squibb
bms.com; sustiva.com
(800) 321-1335


Sustiva 600 mg, 30 tablets:

generic: 600 mg, 30 tablets:

Sustiva 200 mg, 90 capsules:

generic: 200 mg, 90 capsules:

Sustiva 50 mg, 30 capsules:

generic: 50 mg, 30 capsules:

Potential Side Effects and Toxicity

Potential Drug Interactions

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