emtricitabine, tenofovir AF FTC and TAF (two NRTIs)

DHHS recommended as a component of initial regimen for most people
Nucleoside "Nuke"

Standard Dose

One tablet once daily, with or without food. All doses, adult and pediatric, must be taken in combination with another antiretroviral(s) from a different drug class.

For adults and children weighing at least 31 pounds (14 kg). For children who are not also taking a boosted protease inhibitor, use one tablet for children weighing at least 25 kg to less than 35 kg (55 to 77 pounds) and use one pediatric tablet (120 FTC/15 mg TAF) for children weighing at least 14 kg to less than 25 kg (31 to 55 pounds).

Take a missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose. Descovy’s prescribing information indicates that it should not be used if CrCl is less than 30 mL/min, but data have shown that it can be used safely in people with end stage renal disease on hemodialysis and with CrCl less than 15 mL/min. Descovy was approved for HIV prevention (pre-exposure prophylaxis, or PrEP) in October 2019; see “Descovy for PrEP” page.
  • See the individual drugs contained in Descovy: Emtriva (TAF is not available separately for HIV, but is used to treat hepatitis B under the brand name Vemlidy).
  • See package insert for more complete information on potential side effects and interactions.


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