Prezista and Prezcobix

darunavir DRV and darunavir, cobicistat DRV (PI), COBI (PKE)

DHHS recommended as a component of initial regimen in certain clinical situations; also DHHS recommended for rapid ART for people with a history of using Apretude (for PrEP)
Protease Inhibitor

Standard Dose

Prezista: Two different doses available. One 800 mg tablet + 100 mg Norvir or 150 mg Tybost once daily with food for treatment-naïve people (those taking HIV therapy for the first time) and treatment-experienced adults without Prezista-related resistance. For adults and children 3 years of age and older weighing at least 22 pounds (10 kg). Prezista for children is dosed based on weight. There are 75 mg and 150 mg tablets as well as an oral suspension (100 mg/mL) (strawberry cream flavored) available for children age 3 and older and for adults who can’t swallow pills. One 600 mg tablet + 100 mg Norvir twice daily with food for pregnant individuals and for people who have at least one Prezista-related resistance mutation. Prezista should always be taken with Norvir or Tybost. Suspension needs to be taken with Norvir or Tybost, with food. Suspension should be shaken before each use and stored at room temperature. Do not refrigerate.

Prezcobix: One tablet once daily with food, in people with no darunavir-associated drug resistance, including both treatment-experienced and treatment-naïve individuals. For adults and children weighing at least 88 pounds (40 kg). Prezcobix is only available for people taking darunavir once daily, not those who require darunavir twice daily. It is not recommended to co-administer Prezcobix with tenofovir disoproxil fumarate with creatinine clearance (CrCl) less than 70 mL/min.

Must also be taken in combination with another antiretroviral(s) from a different drug class. Do not use either drug in people with severe liver impairment. Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose.
  • See package insert for more complete information on potential side effects and interactions. 


Janssen Therapeutics
(800) JANSSEN (526-7736)


Prezista AWP
600 mg, 60 tablets: $2,514.35/month
800 mg, 30 tablets: $2,514.35/month

Prezcobix AWP

Potential Side Effects and Toxicity

Potential Drug Interactions

More Information

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