Dolutegravir (DTG/3TC)

Initial regimen to consider when ABC, TAF, and TDF cannot be used or are not optimal
Single-Tablet Regimen

Standard Dose

One tablet once daily, without regard to food. Tablet contains 50 mg of the INSTI dolutegravir plus 300 mg of the NRTI lamivudine.

Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose. Lamivudine dosing needs to be adjusted for adults and children who have decreased kidney function (creatinine clearance less than 50 mL/min). See package insert when available for guidance on dosing in the setting of kidney impairment. Dolutegravir is not recommended for people with severe liver impairment.


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