Reyataz and Evotaz

atazanavir sulfate ATV Protease inhibitor and atazanavir/cobicistat ATV/COBI

Recommended as components of initial regimen in certain clinical situations
Protease Inhibitor

Standard Dose

Reyataz: For most treatment-naïve (first time on HIV therapy) and treatment-experienced individuals, the dose is one 300 mg capsule plus 100 mg Norvir or 150 mg Tybost once daily with food. See package insert for dosing recommendations during pregnancy, liver or kidney impairment, and with certain drug interactions. Capsules also available in 150 mg and 200 mg. Take Norvir or Tybost at same time as Reyataz. Swallow capsules whole—do not open or mix with anything. Pediatric dose with 50 mg oral powder available based on body weight for children at least 3 months of age weighing at least 11 pounds (5 kg). Oral powder may be used by adults who cannot swallow the capsules.

Evotaz: One tablet once daily with food in adults and pediatric patients weighing at least 77 pounds (35 kg). Each tablet contains 300 mg of atazanavir boosted by 150 mg cobicistat. Use with Intelence or Sustiva is not recommended. Use in treatment-experienced people depends on protease inhibitor drug resistance. Not recommended for people with any degree of liver impairment or those who are treatment-experienced and on hemodialysis. Evotaz is not recommended during pregnancy due to substantially lower exposures of atazanavir and cobicistat during pregnancy.

Must be taken in combination with another antiretroviral(s) that does not contain this medication or medication from the same drug class(es). Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose.
  • See package insert for more complete information on potential side effects and interactions. 


Bristol-Myers Squibb;
(800) 321-1335


Not available on formulary used

Generic atazanavir
150 mg, 60 capsules: $1,517.10/month
300 mg, 30 capsules: $1,502.76/month


Potential Side Effects and Toxicity

Potential Drug Interactions

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