rilpivirine (RPV)

Recommended as component of initial regimen in certain clinical situations in combination with Descovy or Truvada (as Odefsey or Complera)
Non-Nucleoside "Non-Nuke"

Standard Dose

One 25 mg tablet once daily with a standard meal (more than 390 calories). For adults and children 12 years of age and older weighing at least 77 pounds (35 kg). Must be taken in combination with another antiretroviral(s) which does not contain the medication in this drug or medication from the same drug class. No dose adjustment needed for pregnant patients with undetectable viral load on a stable rilpivirine-based regimen, but monitor viral load closely because lower rilpivirine drug exposure has been seen during pregnancy.

Viral load (HIV RNA) must be less than 100,000 copies/mL and CD4 T-cell count must be above 200 cells/mm3 before starting Edurant due to higher rates of virologic failure in these patients.

Take missed dose as soon as possible with a meal, unless it is closer to the time of your next dose. Do not double up on your next dose.

Must be taken with a meal that you chew—not just nutritional drinks or protein shakes. Taking rilpivirine without food could result in a 40% decrease in drug absorption and may lead to resistance.


Janssen Therapeutics
(800) JANSSEN (526-7736)



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