25 mg rilpivirine RPV (NNRTI)

DHHS recommended as a component of an initial regimen in certain clinical situations in combination with Descovy or Truvada (as Odefsey or Complera)
Non-Nucleoside "Non-Nuke"

Standard Dose

One tablet, once daily with a standard meal. For adults and children (12 years of age and older weighing at least 77 pounds, or 35 kg) taking HIV treatment for the first time (treatment-naïve) with viral load less than or equal to 100,000. Must be taken in combination with another antiretroviral(s) from a different drug class. No dose adjustment needed for pregnant people with undetectable viral load on a stable rilpivirine-based regimen, but monitor viral load closely because lower rilpivirine drug exposure has been observed during pregnancy.

According to DHHS guidelines, viral load (HIV RNA) should be less than 100,000 copies/mL and CD4 T cell count must be above 200 cells/mm3 before starting Edurant due to higher rates of virologic failure in these people. The CD4 requirement, however, is no longer on the drug label.

Take missed dose as soon as possible with a meal, unless it is closer to the time of your next dose. Do not double up on your next dose.

Must be taken with a meal that you chew—not just a nutritional drink or a protein shake, or a light snack. Taking rilpivirine without food could result in up to a 40% decrease in drug absorption and may lead to resistance.
  • See package insert for more complete information on potential side effects and interactions.


Janssen Therapeutics
(800) JANSSEN (526-7736)



Potential Side Effects and Toxicity

Potential Drug Interactions

More Information

Doctor Comments

Activist Comments