Positively Aware Isentress

Isentress HD (and Isentress)

raltegravir RAL (INSTI)

Each is DHHS recommended as a component of initial regimen in certain clinical situations
Integrase Inhibitor

Standard Dose

Isentress HD: Two 600 mg film-coated tablets once daily, with or without food, for individuals new to HIV therapy (treatment-naïve) or who are virologically suppressed (have undetectable viral load) on an initial regimen containing raltegravir.

Isentress: One 400 mg film-coated tablet twice daily, with or without food, for people with HIV treatment experience or individuals who are new to HIV therapy.

Must be taken in combination with another antiretroviral(s) from a different drug class.

Isentress HD is for adults and children weighing at least 88 pounds (40 kg). Isentress is for adults and children weighing at least 4 pounds (2 kg). Both Isentress HD and Isentress can be taken with or without food.

Isentress (but not Isentress HD) pediatric formulations are available as an oral suspension. Isentress dosing is based on weight for children less than 55 pounds; see package insert for dosing and mixing instructions. Do not substitute oral suspension for film-coated tablets.

Take missed dose as soon as possible, unless it’s closer to the time of your next dose. Do not double up on your next dose.
  • See package insert for more complete information on potential side effects and interactions.


Merck and Co.
(800) 622–4477


Isentress HD and Isentress not available on formulary used

Potential Side Effects and Toxicity

Potential Drug Interactions

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