Positively Aware Isentress

Isentress HD (and Isentress)

raltegravir (RAL)

Recommended as component of initial regimen for most people
Integrase Inhibitor

Standard Dose

Isentress HD: Two 600 mg film-coated tablets once daily for individuals new to HIV therapy (treatment-naïve) or who are virologically suppressed (have undetectable viral load) on an initial regimen of Isentress.

Isentress: One 400 mg film-coated tablet twice daily for people with HIV treatment experience; this Isentress dose may also be taken by those new to HIV therapy.

Isentress HD is for adults and children weighing at least 88 pounds (40 kg). Isentress is for adults and children weighing at least 4 pounds (2 kg). Both Isentress HD and Isentress can be taken without regard to food.

Isentress (but not Isentress HD) pediatric formulations are available as an oral suspension and flavored chewable tablets. Isentress dosing is based on weight for children less than 55 pounds; see package insert for dosing. The chewable tablets may be chewed or swallowed whole. Do not substitute chewable tablets or oral suspension for film-coated tablets.

Take missed dose as soon as possible, unless it’s closer to the time of your next dose. Do not double up on your next dose.


Merck and Co.
(800) 622–4477


Isentress HD: $1,800/month
Isentress 400 mg: $1,800/month

Potential Side Effects and Toxicity

Potential Drug Interactions

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