DHHS HIV treatment guidelines for first-time therapy
Most patients new to antiretroviral therapy should start on one of six regimens:
NRTIs: Nucleoside Reverse Transcriptase Inhibitors
NNRTIs: NON-Nucleoside Reverse Transcriptase Inhibitors
PIs: Protease Inhibitors
INSTIs: Integrase Inhibitors
EIs: Entry Inhibitors
STRs: Single-Tablet Regimens
A regimen should be individualized on the basis of virologic efficacy (suppression of viral load to less than 50 copies per mL), toxicity, pill burden, dosing frequency, drug-drug interaction potential, resistance testing results, comorbid conditions (such as kidney disease, hepatitis B or C, etc.), and cost. More details including the strength of each recommendation and those for pregnant women are in the documents from the U.S. Department of Health and Human Services (DHHS) online. AIDSinfo has mobile applications that allow access to federally approved HIV/AIDS treatment and research information and are offered free of charge, including a Guidelines app, at aidsinfo.nih.gov/apps.
