Understanding HIV treatment doesn’t need to be difficult. Below are tips to help give you the knowledge you need to work with your providers to make empowered, informed choices about your treatment. Medications that are included in the 20th Annual HIV Drug Guide are the most commonly used drugs in the U.S. that are FDA approved, as well as those that are expected to be approved this year.

There are several changes to this year’s HIV Drug Guide that will improve your experience and the way that you use this guide.

A new drug order 

When we started this guide 20 years ago, we listed drugs in the order they were approved. There have been several variations since then in how drugs have been listed in the guide as new treatments and new classes of drugs became available. Today, with so many good options out there, we highlight those drugs that are the best options and list them first, followed by most commonly prescribed drugs in the five drug classes in alphabetical order. Older drugs that are no longer used or infrequently prescribed are available only online at positivelyaware.com, and the pages are no longer being updated. This includes some of the oldest HIV drugs that either have intolerable side effects or for which there are better options now available.

Recommendations for use

The Department of Health and Human Services (DHHS) and the International AIDS Society-USA (IAS-USA) both publish recommendations for the use of HIV antiretroviral drugs. These recommendations focus on drug regimens more than single agents, but are essential tools that help providers and individuals choose a regimen that’s best suited for them. We include information on some of these recommendations on page 18, at the top of each drug page, as well as the pullout drug chart. DHHS and IAS-USA guidelines are very similar in their recommendations, so for consistency we reference the DHHS guidelines. For the full list of recommendations go to aidsinfo.nih.gov or iasusa.org/guidelines.

Drug classes and co-formulations

A fixed-dose combination (FDC) combines two or more drugs in one tablet, such as Prezcobix (darunavir/cobicistat). A single-tablet regimen (STR) contains drugs from different classes and is a complete regimen in one pill, such as Triumeq (dolutegravir/lamivudine/abacavir). Atripla, Complera, Genvoya, Stribild, and Triumeq are the five single-tablet regimens that are now available.

When a drug is a co-formulation (combination) of different drugs, the generic names will be separated by slashes—for example, Genvoya is the co-formulation of elvitegravir/cobicistat/emtricitabine/TAF. 

Remember that anti-HIV drugs should always be taken in combination using two or more drug classes (for example, an integrase inhibitor plus two non-nukes). While not a drug class, single-tablet regimens (STRs) are in their own category. STRs are widely used for first-time treatment and for their convenience, but they are not for everybody. For those who are treatment-experienced or have multi-drug resistance, they may not be able to use these STRs and will still have to combine two to three or more single agents from different drug classes, the old-fashioned way.

There are also several non-HIV drugs that are used commonly by people with HIV which are included in this guide. In addition, there is a Truvada for PrEP (pre-exposure prophylaxis, for prevention) page that is available online.

Drug names

When a drug is in development and before it’s approved, it’s first given a “generic” name (such as dolutegravir), which health care providers may identify it with even after approval. Once it is approved, it’s given its brand name (Tivicay is the brand name of dolutegravir), which most people know it by. At medical conferences and in publications you will often see three-character abbreviations used (DTG in the case of dolutegravir). A good rule of thumb is, brand names are always capitalized and generic names are always lower case. Within each drug’s page, you will see the drug referred to by any or all of its names. 

All of each drug’s names appear at the top of its page and also on the pullout drug chart, so if you’re confused, look them up there!

Viread (tenofovir) is a drug of special circumstances. It is the only “nuke” that is a nucleotide reverse transcriptase inhibitor, as opposed to nucleoside; however, both types of nukes have a similar mechanism of action. Viread is also in three out of the four single-tablet regimens (STRs) currently available, as well as being one of the two drugs in Truvada, the only drug FDA approved for PrEP. You’ll also notice that Viread is referred to by its generic name, tenofovir DF (disoproxil fumarate)—another version, tenofovir alafenamide (TAF), is part of the STR Genvoya. As this issue went to press, two new TAF-containing co-formulations were expected to be approved in the next two months, the single-tablet regimen RPV/FTC/TAF (a new version of Complera containing TAF instead of TDF), and the fixed dose combination F/TAF (a new TAF-based version of Truvada).

Drug price and access

The Average Wholesale Price (AWP) is a way to compare costs of drugs. It is not necessarily what you would pay if you had to pay the full retail price.

HIV drugs are not cheap and with all the continuing changes in drug coverage due to the Affordable Care Act (ACA), figuring out how to pay for them can be a challenge. Luckily, there are programs that can help cover all or part of the costs and facilitate access. Of course many of us take drugs for conditions other than HIV, so in our drug co-pay and patient assistance program chart we include information on drugs used to treat HIV as well as several other non-HIV drugs.

Navigating your treatment

There is a wealth of information available about HIV and the drugs used to treat it. Knowing where to look and understanding some of the basics will help you sort through it all, giving you peace of mind and the knowledge you need to live a better, healthier life with HIV.


You can easily read about each drug online by typing the drug’s name after our URL. For example, find the Drug Guide’s page for Isentress by typing positivelyaware.com/isentress.