Symfi and Symfi Lo

Single-tablet regimens containing an NNRTI and two NRTIs, efavirenz/lamivudine/tenofovir disoproxil fumarate EFV/3TC/TDF

Recommended initial regimens in certain clinical situations
Single-Tablet Regimen

Standard Dose

One tablet once daily on an empty stomach, preferably at bedtime (food increases the risk of central nervous system, or CNS, side effects). The Symfi tablet contains 600 mg of the NNRTI efavirenz plus 300 mg lamivudine and 300 mg tenofovir DF (TDF). The Symfi Lo tablet contains a lower dose of efavirenz, 400 mg, plus 300 mg lamivudine and 300 mg tenofovir DF (TDF).

For adults and pediatric patients weighing at least 77 pounds (35 kg) for Symfi Lo and 88 pounds (40 kg) for Symfi.

Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose. Do not split or crush the tablet. Dose cannot be adjusted for people with kidney problems. Symfi and Symfi Lo are not recommended for people with CrCl less than 50 mL/min or individuals requiring dialysis. Symfi or Symfi Lo should not be used in people with moderate or severe kidney or liver impairment.
  • See the individual drugs contained in Symfi and Symfi Lo: Sustiva, Epivir, and Viread. See also similar STR, Atripla. 
  • See package insert for more complete information on potential side effects and interactions.


(877) 446-3679


Symfi: $1,961.33/month
Symfi Lo: $1,961.33/month

Potential Side Effects and Toxicity

Potential Drug Interactions

More Information

Doctor Comments

Activist Comments