Generic drug bottle

Rebetol; ribavirin

ribavirin (RBV)

FDA approved for use in HIV/HCV co-infection
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Standard Dose

Ribavirin dosage depends on several factors, including indication for treatment, patient lab values, and patient tolerability. It is given in either fixed doses or in doses related to weight (weight-based). The dose range is 600 mg to 1,200 mg per day taken in two divided doses. Ribavirin is now only available as a generic tablet or capsule; other products have been discontinued. It must be taken with food. Ribavirin may be added to direct-acting antiviral (DAA) therapy in people that have severe hepatic impairment (decompensated cirrhosis) or in people who have certain resistance mutations that make the DAA less effective. It should never be taken by itself for treatment of hepatitis C. Use of ribavirin is contraindicated in people with creatinine clearance (CrCl) less than 50 mL/min.

Take missed dose as soon as possible unless it is less than 12 hours until your next dose. Do not double up on your next dose.


Generic capsules/tablets: Manufacturers vary


AWP (based on 1,200mg/day dosing)
Generic 200 mg tablet: $1,389 / month
Generic 200 mg capsule: $1,601–$1,668 / month

Potential Side Effects and Toxicity

Potential Drug Interactions

More Information