Generic drug bottle

Rebetol; ribavirin

ribavirin (RBV)

FDA approved for use in HIV/HCV co-infection
Genotype
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Standard Dose

Ribavirin dosage depends on several factors, including the brand used, indication for treatment, patient lab values, and patient tolerability. It is given in either fixed doses or in doses related to weight (weight-based). The dose range is 600 mg to 1,200 mg per day taken in two divided doses. Depending upon the manufacturer, tablets are available in 200 mg, 400 mg, 500 mg, and 600 mg. Ribavirin solution (liquid) and generic tablets are also available. The authorized generic was created to help lower cost and has identical ingredients as the brand name. It must be taken with food. Ribavirin may be added to direct-acting antiviral (DAA) therapy in people that have severe hepatic impairment (decompensated cirrhosis) or in people who have certain resistance mutations that make the DAA less effective. It should never be taken by itself.

Dose adjustment in patients with kidney dysfunction varies based on brand used. In general, use of ribavirin is contraindicated in people with creatinine clearance (CrCl) less than 50 mL/min.

Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose.

Manufacturer

Rebetol (solution): Merck

AWP

AWP (based on 1,200 mg/day dosing)
Rebetol (solution): $1,960 / month;
Generic 200 mg tablet: $222–$1,670 / month
Generic 200 mg capsule: $230–$1,668 / month
Generic capsules/tablets: Manufacturers vary

Potential Side Effects and Toxicity

Potential Drug Interactions

More Information