DRV/COBI darunavir/cobicistat

Recommended as a component of initial regimen in certain clinical situations
Protease Inhibitor

Standard Dose

One tablet (800 mg of the PI darunavir boosted by 150 mg cobicistat) once daily with food, in people with no darunavir-associated drug resistance, including both treatment-experienced individuals and those who are treatment-naïve (taking HIV therapy for the first time). Must be taken in combination with another antiretroviral(s) which does not contain the medications in this drug or medication from the same drug classes.

Prezcobix is for adults and children weighing at least 88 pounds (40 kg). Prezcobix is only available for people taking darunavir once daily, not those who require darunavir twice daily (see Prezista). It is not recommended to co-administer Prezcobix with tenofovir disoproxil fumarate (brand name Viread, found in Truvada), with creatinine clearance (CrCl) less than 70 mL/min (a measure of kidney function). See “More information” for CrCl information.
Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose. Prezcobix is not recommended during pregnancy due to substantially lower exposures of darunavir and cobicistat during pregnancy. Do not use in people with severe liver impairment.
  • See the individual drugs contained in Prezcobix: Prezista and Tybost.
  • See package insert for more complete information on potential side effects and interactions.


Janssen Therapeutics; (800) JANSSEN (526-7736)



Potential Side Effects and Toxicity

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