Positively Aware Isentress

Isentress and Isentress HD

RAL raltegravir

Recommended as a component of initial regimen for most people
Integrase Inhibitor

Standard Dose

Isentress HD: Two 600 mg film-coated tablets once daily without regard to food for individuals new to HIV therapy (treatment-naïve) or who are virologically suppressed (have undetectable viral load) on an initial regimen containing Isentress.

Isentress: One 400 mg film-coated tablet twice daily without regard to food for people with HIV treatment experience; this Isentress dose may also be taken by those new to HIV therapy.

Must be taken in combination with another antiretroviral(s) which does not contain this medication or medication from the same drug class.

Isentress HD is for adults and children weighing at least 88 pounds (40 kg). Isentress is for adults and children weighing at least 4 pounds (2 kg). Both Isentress HD and Isentress can be taken without regard to food.

Isentress (but not Isentress HD) pediatric formulations are available as an oral suspension and flavored chewable tablets. Isentress dosing is based on weight for children less than 55 pounds; see package insert for dosing. The chewable tablets may be chewed or swallowed whole. Do not substitute chewable tablets or oral suspension for film-coated tablets.

Take missed dose as soon as possible, unless it’s closer to the time of your next dose. Do not double up on your next dose
  • See package insert for more complete information on potential side effects and interactions.


Merck and Co.
(800) 622–4477


Isentress HD 600 mg, 60 tablets: $2,185.92/month
Isentress 100 mg, 60 chewables: $546.48/month
Isentress 100 mg, 60 packets: $546.48/month
Isentress 400 mg, 60 tablets: $2,185.92/month

Potential Side Effects and Toxicity

Potential Drug Interactions

More Information

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