Positively Aware Epivir


3TC lamivudine

Recommended as a component of initial regimen for most people
Nucleoside "Nuke"

Standard Dose

One 300 mg tablet once daily (or one 150 mg tablet twice daily), without regard to food. Dosing needs to be adjusted for adults and children who have decreased kidney function (creatinine clearance less than 50 mL/min). This medication, however, is often used in reduced renal function below 50 mL/min due to relatively minimal risk of lamivudine accumulation and side effects. See package insert for guidance on dosing in the setting of kidney impairment. Must be taken in combination with another antiretroviral(s).

According to the package insert, it is indicated for adults and children at least 3 months of age. Based on pediatric DHHS guidelines, it can be used as part of a presumptive HIV regimen in infants of at least 32 weeks’ gestation at birth for higher risk perinatal HIV exposure. Epivir for children is dosed based on body weight. See the package insert or DHHS guidelines for weight-based dosing.

Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose. The 150 mg tablets are scored and may be split. Based on drug properties, tablets may be crushed and added to a small amount of semi-solid food or liquid for immediate consumption. Epivir is also available as an oral solution (10 mg/mL) (strawberry-banana flavor) for children and adults who are not able to swallow the tablets. Epivir can be substituted for Emtriva.
  • See package insert for more complete information on potential side effects and interactions.


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Epivir not available on formulary used

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