Positively Aware Epivir


lamivudine (3TC)

Recommended as component of initial regimen for most people when used in combination with dolutegravir and abacavir
Nucleoside "Nuke"

Standard Dose

One 300 mg tablet once daily (or one 150 mg tablet twice daily), without regard to food. Dosing needs to be adjusted for adults and children who have decreased kidney function (creatinine clearance less than 50 mL/min). See package insert for guidance on dosing in the setting of kidney impairment. Must be taken in combination with another antiretroviral(s), which does not contain the medication in this drug.

According to the package insert, it is indicated for adults and children at least 3 months of age and older. Based on pediatric DHHS guidelines, it can be used as part of an empiric HIV regimen in infants of at least 32 weeks’ gestation at birth for higher risk perinatal HIV exposure. Epivir for children is dosed based on body weight. See the package insert and/or DHHS guidelines for weight-based dosing.

Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose. The 150 mg tablets are scored and may be split. Based on drug properties, tablets may be crushed and added to a small amount of semi-solid food or liquid for immediate consumption. Epivir is also available as an oral solution (10mg/mL) (strawberry-banana flavor) for children and adults who are not able to swallow the tablets. Can be substituted for Emtriva.


ViiV Healthcare
(877) 844-8872


Epivir 300 mg tablets, 30 tablets: $498.89/month
generic lamivudine; 300 mg tablets, 30 tablets: $429.19/month

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